Veterinary Rx

[Veterinary Drug Name]

Generic name: Enrofloxacin Soluble Powder

Trade name:

English name: Enrofloxacin Soluble Powder

Pinyin: Ennuoshaxing Kerongxingfen

[Main Ingredients] Enrofloxacin

[Description] This drug is of white to light yellow powder.

[Pharmacological Action] Pharmacodynamics: Enrofloxacin is a broad-spectrum bactericidal drug specifically for animals and belongs to the fluoroquinolone class. It is effective against Escherichia coli, Salmonella, Klebsiella, Pasteurella, Proteus, Serratia marcescens, Corynebacterium pyogenes, Staphylococcus aureus, mycoplasma, and chlamydia. Besides, its efficacy against Pseudomonas aeruginosa and Streptococcus is weaker, and it has minimal effect on anaerobic bacteria. Enrofloxacin can exhibit a significant post-antibiotic effect on sensitive bacteria. Therefore, the antibacterial mechanism of this drug involves inhibiting bacterial DNA gyrase, interfering with the replication, transcription, and repair recombination of bacterial DNA, and results in death of bacteria due to their inability to grow and reproduce normally.

Pharmacokinetics: This drug is well absorbed in most animals when administered orally. In chickens, the bioavailability after oral administration is 62.2% to 84%. It is widely distributed within the body and penetrates well into tissues and body fluids, including bone; with the exception of cerebrospinal fluid, drug concentrations in nearly all tissues are higher than in plasma. Hepatic metabolism primarily involves the removal of the ethyl group from the 7-piperazinyl ring to form ciprofloxacin, followed by oxidation and glucuronidation. The primary route of elimination is through the kidneys (via tubular secretion and glomerular filtration), with 15 to 50% excreted unchanged in the urine. The elimination half-life of this drug after oral administration in chickens is 9.1-14.2 hours.

[Drug Interaction] (1) This drug has a synergistic effect when used in combination with aminoglycosides or broad-spectrum penicillins. (2) Heavy metal ions such as Ca²⁺, Mg²⁺, Fe³⁺, and Al³⁺ can chelate with this drug and affect its absorption. (3) When used concurrently with theophylline or caffeine, it can reduce the plasma protein binding rate, and lead to abnormally high concentrations of theophylline and caffeine in the blood, and even symptoms of theophylline toxicity may occur. (4) This drug inhibits hepatic drug enzymes, which can reduce the clearance rate of drugs primarily metabolized in the liver, and lead to increased blood drug concentrations. (5) Probenecid can inhibit its renal tubular secretion and excretion, resulting in a prolonged half-life.

[Function and Use] Fluoroquinolone antibacterial drug, for the treatment of bacterial diseases and mycoplasma infections in chickens and racing pigeons.

[Dosage and Administration] On the basis of this drug. Mixed drinking: 0.5-1.5g per 1L of water for chickens, twice a day, administered for 3-5 consecutive days; 5g per 1L of water for racing pigeons, administered for 3-5 consecutive days.

[Adverse Reaction] (1) It can cause degeneration of cartilage in young animals, leading to lameness and pain.

(2) Gastrointestinal reactions include vomiting, abdominal pain, and bloating.

(3) Skin reactions include erythema, itching, urticaria, and photosensitivity reactions.

[Precautions] (1) This drug cannot be used for hens laying eggs for human consumption during the laying period.

(2) It is prohibited in gallus gellusdemesticus brissen.

[Withdrawal Period] 8 days for chickens.

[Specification] 5%

[Package] 100g/packet × 10 packets/box × 8 boxes/carton

[Storage] It should be kept out of light and sealed in a dry place for storage.

[Shelf Life] 2 years

[Production License No.] (2022) SYSCZZ No. 08019

[GMP Certificate No.] (2022) SY GMP ZZ No. 08010

[Approval No.] SYZ No. 080192119

[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)