Veterinary OTC

[Veterinary Drug Name]

Generic name: Praziquantel Tablets

Trade name:

English name: Praziquantel Tablets

Pinyin: Bikuitong Pian

[Main Ingredients] Praziquantel

[Description] This drug is of white tablets.

[Pharmacological Action] Pharmacodynamics: Praziquantel has broad-spectrum anti-schistosome and anti-tapeworm effects. Praziquantel is extremely active against adults of various tapeworms and also has good activity against larvae. Praziquantel is a good anthelmintic for schistosome.

The exact mechanism of action of praziquantel on tapeworms has not been determined, and it may be that it interacts with the phospholipids of the worm envelope, with the resultant efflux of sodium, potassium, and calcium ions. In vitro, low concentrations of praziquantel appear to impair the sucker function of the tapeworm and stimulate peristalsis, while higher concentrations enhance contraction of the tapeworm strobila (proglottid strobila) (irreversible contraction at very high concentrations). In addition, praziquantel can cause the formation of focal vacuoles in specific parts of the tapeworm envelope, followed by lysis of the worm. In schistosomes and trematodes, praziquantel may kill the parasite directly due to increased calcium ion flow into the worm, followed by the formation of focal vacuoles and phagocytosis.

Pharmacokinetics: The product is quickly and almost completely absorbed after oral administration, but there is a significant first-pass effect. The plasma peak concentration is reached at 0.5 to 2 hours and 2 hours after dosing in dogs and sheep, respectively. Intramuscular and subcutaneous injections maintain the plasma concentration longer than oral administration. Praziquantel is distributed in various tissues throughout the body, with the highest content in the liver and kidney, and can cross the blood-brain barrier into the central nervous system. This wide distribution facilitates the expulsion of larvae from various organs of the host (muscle, brain, viscera, and abdominal cavity). Praziquantel that enters the body is rapidly metabolized by the liver to inactive monohydroxylated or polyhydroxylated metabolites that are excreted primarily in the urine. The elimination half-lives for oral administration are 7.7 hours for cattle, 1.1 to 2.5 hours for sheep and pigs, and 3 to 3.5 hours for dogs and rabbits. Only a very small amount of the prototype drug (0.1% in sheep) is excreted in urine or feces.

[Drug Interaction] When combined with albendazole and dexamethasone, it reduces the plasma concentration of praziquantel.

[Function and Use] Antihelmintic, mainly used for schistosomiasis in animals, and also for tapeworms and cysticercosis.

[Dosage and Administration] Oral administration: 0.2-0.7 tablets/time per 10kg of body weight for cattle, sheep, and pigs; 0.05-0.1 tablets/time per 10kg of body weight for dogs and cats; 0.2-0.4 tablets/time per 10kg of body weight for poultry.

[Adverse Reaction] (1) At high doses, mild elevations of serum alanine transaminase are occasionally seen in cattle, and some cattle may develop elevated body temperature, muscle tremors, and ruminal tympany.

(2) Oral administration to dogs may cause anorexia, vomiting, or diarrhea, but the incidence is less than 5%, and adverse reactions in cats are rare.

[Precautions] (1) It should be used with caution for puppies under 4 weeks of age and kittens under 6 weeks of age.

(2) Praziquantel formulated with Febantel can be used in dogs and cats of all ages and is also safe for use in pregnant dogs and cats.

[Withdrawal Period] 28 days; 7 days for the weaning period.

[Specification] 0.5g

[Package] 100 tablets/bottle × 60 bottles/carton

[Storage] It should be kept out of light and tightly sealed for storage.

[Shelf Life] 2 years

[Production License No.] (2022) SYSCZZ No. 08019

[GMP Certificate No.] (2022) SY GMP ZZ No. 08010

[Approval No.] SYZ No. 080191175

[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)