Veterinary Rx
[Veterinary Drug Name]
Generic name: Lincomycin Hydrochloride Injection
Trade name:
English name: Lincomycin Hydrochloride Injection
Pinyin: Yansuan Linkemeisu Zhusheye
[Main Ingredients] Lincomycin hydrochloride
[Description] This drug is of colorless to faint yellow or faint yellow-green transparent liquid.
[Pharmacological Action] Pharmacodynamics: Lincomycin belongs to the lincosamide class of antibiotics and acts as a bacteriostatic agent. It is effective against bacteria such as Staphylococcus aureus (including penicillin-resistant strains), Streptococcus, Streptococcus pneumoniae, Bacillus anthracis, Erysipelothrix rhusiopathiae, certain mycoplasmas (mycoplasma hyopneumoniae, mycoplasma hyorhinis, mycoplasma hyosynoviae), Leptospira, and anaerobic bacteria (such as Fusobacterium, Clostridium tetani, Clostridium perfringens, Actinomycetes, etc.). It exerts its antibacterial effect by inhibiting protein synthesis through acting on the 50S subunit of bacterial ribosomes, thus affecting the elongation of the peptide chain.
Pharmacokinetics: After intramuscular injection, it is rapidly absorbed. In pigs, a single intramuscular dose of 11 mg/kg results in a peak plasma concentration of 6.25 µg/ml. The plasma protein binding rate is 57% to 72%. It has a wide distribution within the body, with an apparent volume of distribution in pigs of 2.8 L/kg. It extensively distributes into various body fluids and tissues (including bone), with the highest concentrations found in liver and kidney. Tissue drug levels are several times higher than concurrent serum levels. It can cross the placenta but does not easily pass through the blood-brain barrier; during inflammation, it is also difficult for the drug to reach effective concentrations in cerebrospinal fluid. It can distribute into milk at concentrations similar to those in plasma. Some of the drug is metabolized in the liver, and both the original drug and its metabolites are excreted via bile, urine, and milk. Excretion in feces can be delayed for several days, thus having an inhibitory effect on sensitive microorganisms in the intestine.
[Drug Interaction] (1) When used together with gentamicin, it has a synergistic effect on Gram-positive bacteria such as Staphylococcus and Streptococcus.
(2) When used together with aminoglycosides and polypeptide antibiotics, it may enhance the blockade of neuromuscular junctions. When combined with erythromycin, there is an antagonistic effect due to the same site of action, with erythromycin having a higher affinity for the 50S subunit of bacterial ribosomes than this drug.
(3) It is inappropriate to be used together with antidiarrheal drugs that inhibit intestinal motility or contain kaolin.
(4) There are compatibility contraindications with kanamycin, neomycin, etc.
[Function and Use] Lincosamide antibiotic, for the treatment of infections caused by Gram-positive bacteria and also suitable for infections such as swine treponematosis and mycoplasmosis.
[Dosage and Administration] Intramuscular injection: 0.033 ml/time per 1kg of body weight for pigs, administered once a day; 0.033 ml/time per 1kg of body weight for dogs and cats, administered twice a day for 3-5 consecutive days.
[Adverse Reaction] It has a neuromuscular blocking effect.
[Precautions] Intramuscular injection administration may cause transient diarrhea or soft stool. Such situation is very rare. However, if it occurs, necessary measures should be taken to prevent dehydration.
[Withdrawal Period] 2 days for pigs.
[Specification] 100ml: 30g on the basis of C18H34N2O6S
[Package] 100ml/vial × 50 vials/carton
[Storage] It should be tightly sealed for storage.
[Shelf Life] 2 years
[Production License No.] (2022) SYSCZZ No. 08019
[GMP Certificate No.] (2022) SY GMP ZZ No. 08010
[Approval No.] SYZ No. 080191769
[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)
