Veterinary OTC
[Veterinary Drug Name]
Generic name: Flunixin Meglumine Injection
Trade name:
English name: Flunixin Meglumine Injection
Pinyin: Funixin Pujia’an Zhusheye
[Main Ingredients] Flunixin Meglumine
[Description] This drug is of colorless or light yellow transparent liquid.
[Pharmacological Action] Pharmacodynamics: As a potent cyclooxygenase inhibitor, flunixin meglumine has analgesic, antipyretic, anti-inflammatory, and anti-rheumatic effects. The analgesic effect refers to blocking the transmission of pain impulses by the inhibition of the synthesis of peripheral prostaglandins or their pain sensitizers, or their combined action. The anti-inflammatory effect of peripheral tissues may be caused by inhibiting cyclooxygenase, reducing the formation of prostaglandin precursors, and inhibiting other mediators to induce local inflammatory responses.
Pharmacokinetics: After a single intramuscular injection in pigs (body weight of 2.2mg/kg), the half life of plasma elimination is 3-4 hours, and the peak concentration is 2.94μg/ml, with a peak time of 0.4 hours. The drug can still be detected in the blood 18 hours after administration. In addition, the apparent distribution volume is 2.0L/kg, and the bioavailability of a single neck injection is 87%.
[Drug Interaction] (1) Flunixin meglumine should not be used together with other nonsteroidal anti-inflammatory drugs as it can exacerbate gastrointestinal toxicity, such as ulcers and bleeding.
(2) Due to high plasma protein binding, when used in combination with other drugs, flunixin meglumine may displace other drugs bound to plasma proteins or be displaced itself, potentially enhancing the effects of the displaced drug and causing toxicity.
(3) It can be used in conjunction with antibiotics for the supportive treatment of agalactia syndrome in sows.
[Function and Use] Antipyretic and analgesic anti-inflammatory drug. Used for livestock and small animal fever, inflammatory diseases, muscle pain, and soft tissue pain, etc.
[Dosage and Administration] Intramuscular and intravenous injection: 0.4 ml/time per 10kg of body weight for cattle and pigs; 0.2-0.4 ml/time per 10kg of body weight for dogs and cats; once or twice a day, administered for no more than 5 consecutive days.
[Adverse Reaction] Intramuscular injection may cause local irritation. Long-term high-dose use of this drug may lead to gastric ulcers and kidney function damage in animals.
[Precautions] It should be used cautiously in animals with gastrointestinal ulcers.
[Withdrawal Period] 28 days for cattle and pigs.
[Specification] 100ml: 5g on the basis of C14H11F3N2O2
[Package] 100ml/vial × 50 vials/carton
[Storage] It should be kept out of light and tightly sealed for storage.
[Shelf Life] 2 years
[Production License No.] (2022) SYSCZZ No. 08019
[GMP Certificate No.] (2022) SY GMP ZZ No. 08010
[Approval No.] SYZ No. 080192102
[Executive Standard] Volume I of Veterinary Pharmacopoeia of the People’s Republic of China (2020 Edition)
